Dependence of androgenization on differentiation of the hypothalamic centers

• DOI: 10.1007/bf00800129
• Publication Date: 2004-12-14T04:32:34Z
• Authors: I. I. Dedov; N. A. Demina
• Keywords: 0303 health sciences; 03 medical and health sciences

Dependence of the sterilizing action of androgens on the level of differentiation of the hypothalamic centers in the postnatal period of development was studied in female rats. Asynchronous development of the arcuate nucleus (AN; the tonic center) and the suprachiasmatic nucleus (SCN; the cyclic center) was found. Neurons of AN begin to produce granules of secretion in 20-day embryos. The first neurons with granules of secretion are found in SCN in rats aged 5–7 days. Injection of testosterone propionate induces an anovulatory cycle in females during the first 7 days after birth, on account of inhibition of development of the hypothalamic cyclic center.