Quantitative characteristics of the rapid regeneration of hematopoiesis phenomenon following thymocyte transplantation

• DOI: 10.1007/bf00809878
• Publication Date: 2004-12-14T09:49:19Z
• Authors: Yu. I. Zimin; M. I. Fedotova
• Keywords: 0303 health sciences; 03 medical and health sciences

Quantitative characteristics of the phenomenon of rapid postirradiation regeneration of the bone marrow following transplantation of syngeneic thymocytes were obtained in experiments on (CBA x C57BL)F1 hybrid mice. Within the range 106–108 cells the effect was shown to be independent of the number of transplanted thymocytes. Transplantation in the first 12 h after irradiation was equally effective as regards stimulation of regeneration of the bone marrow. The phenomenon did not appear under the following conditions: a) transplantation of thymocytes 24 h after irradiation; b) irradiation of the recipients in a dose of 600–700 R; c) irradiation of a suspension of thymocytes in vitro in a dose of 10 kR followed by incubation at 37°C for 6–7 h; d) irradiation of the thymocytes in vitro in a dose of 200 kR.