A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: A double-site model for drug absorption

• DOI: 10.1007/bf01066319
• Publication Date: 2005-01-29T18:05:15Z
• Authors: Yves Plusquellec; G. Campistron; S. Staveris; J. Barre; L. Jung; J. P. Tillement; G. Houin
• Keywords: Capsule

Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations--intravenous infusion, oral solution, and oral capsules--in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.