Prostacyclin-like activity of endothelium and subendothelium — important for atherosclerosis?

• DOI: 10.1007/bf01932360
• Publication Date: 2005-07-25T05:36:00Z
• Authors: K. Silberbauer; H. Sinzinger; Maya Winter; W. Feigl; F. Ring
• Keywords: Male; 0301 basic medicine; 03 medical and health sciences; 0302 clinical medicine; Platelet Aggregation; Arteriosclerosis; Prostaglandins; Animals; Aorta, Abdominal; Endothelium; Rabbits; Epoprostenol; Rats

Morphological control of Moncada's bioassay for prostacyclin (PG I2) activity measurement shows that the activity depends not only on endothelium, but in important amounts on subendothelial tissue too. Therefore, it can be concluded that platelet thrombus formation after endothelial cell injury does not depend only on the PG I2-producing ability of the tissue.