ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE

• DOI: 10.1007/bf01954238
• Publication Date: 2005-07-31T18:40:04Z
• Authors: T. Watanabe; A. Morimoto; Y. Sakata; N. Murakami
• Keywords: ACTH secretion

We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha). The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2.