Contribution to the study of fungistatic action of N,N'-bis-n-butylamid of 2,2' dicarboxydiphenyldisulfide (OD 507)

• DOI: 10.1007/bf02050838
• Publication Date: 2005-08-11T21:57:29Z
• Authors: F. Gatti; J. Ceballos; C. Rossetti
• Keywords: Pseudallescheria; Cryptococcus; Antifungal Agents; Histoplasma; Fungi; Phialophora; Humans; Sulfides; Candida; 3. Good health

The authors have studied the fungistatic action in vitro of N,N'-bis-n-butylamide of 2,2' dicarboxydiphenyldisulfide (OD 507) on some strains ofC. albicans, C. neoformans, M. apiospermum, H. duboisii, P. pedrosoi andE. coronata isolated from human fungal infections (both superficial and deep) in Congo. Considering that this substance has an important fungistatic action on the strains studied and that its inhibitory action maintains itself satisfactorily even in presence of human blood (though to somewhat lesser extent), the authors think it usefull to report the results obtained and suggest further research on animals with a view to investigate the possibility of using this substance parenterally on deep human fungal infections.