Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas

• DOI: 10.1007/bf02053502
• Publication Date: 2005-08-13T21:49:17Z
• Authors: Luca Roncucci; Paola Di Donato; Livio Carati; Alberto Ferrari; Mario Perini; Giorgio Bertoni; Giuliano Bedogni; Bruno Paris; Fausto Svanoni; Mario Girola; Maurizio Ponz de ...
• Keywords: Lactulose; Polypectomy

Colonic adenomas represent the natural precursor lesions of most colorectal cancers. The treatment choice is endoscopic polypectomy. However, after removal, polyps recur in a large fraction cases. Thus, we evaluated effect antioxidant vitamins or lactulose on recurrence rate adenomatous polyps. After polypectomy, 255 individuals were randomized into three groups. Group 1 was given vitamin A (30,000 IU/ day), C (1 g/day), and E (70 mg/day); 2 (20 g/day); 3 received no treatment. Forty-six subjects had to be excluded because histologic diagnosis not consistent with adenoma. remaining 209 included analysis according "intention treat" criterion, though 34 did adhere scheduled lost during follow-up. Subjects followed at regular intervals for an average 18 months. Polyps recurring before one year from index colonoscopy considered missed by endoscopist. In evaluable subjects, percentages 5.7 percent, 14.7 35.9 percent vitamins, lactulose, untreated groups, respectively. free adenomas, estimated Kaplan-Meier survival curves, significantly different among groups (log-rank chisquared =17.138;P< 0.001). Using Cox's regression analysis, only variable that contributed model (regression coefficient=0.905;P<0.001). conclusion, either or, lesser extent, lower bowel can proposed as chemopreventive agents, least high-risk individuals.