Antioxidant activities of tocopherols on Fe2+‐ascorbate‐induced lipid peroxidation in lecithin liposomes

• DOI: 10.1007/bf02535334
• Publication Date: 2006-12-05T07:28:30Z
• Authors: Kenji Fukuzawa; Akira Tokumura; Setsuhiro Ouchi; Hiroaki Tsukatani
• Keywords: Lipidology

The antioxidant activities of 4 tocopherols, tocol, and a water-soluble model analog alpha-tocopherol were compared. Egg lecithin liposomes used oxidation was catalyzed by Fe2+-ascorbate. decreased in the order alpha greater than beta gamma delta-tocopherol agreement with their potencies vivo. least effective. Activity depended on molar ratio to unsaturated lipid, one molecule each alpha-, beta-, gamma-, tocol capable protecting, respectively, 220, 120, 100, 30 20 molecules polyunsaturated fatty acid. mechanism possible effect compounds is discussed.