Intestinal and liver fatty acid binding proteins differentially affect fatty acid uptake and esterification in L‐cells

• DOI: 10.1007/bf02537481
• Publication Date: 2006-11-29T20:12:17Z
• Authors: Daniel R. Prows; Eric J. Murphy; Friedhelm Schroeder
• Keywords: Glycerophospholipids; Acyl-CoA

Abstract Differential effects of intestinal (I‐FABP) or liver (L‐FABP) fatty acid binding proteins on uptake and esterification were examined using transfected mouse L‐cell fibroblasts. L‐FABP, but not I‐FABP, expression increased the initial rate extent cis ‐parinaric by 50 29%, respectively, compared to control cells. I‐FABP L‐FABP preferentially [ 3 H]‐oleic incorporation into triacylglycerols 5.5‐fold 3.8‐fold, respectively. While both increasedesterification ethanolamine glycerophospholipids, these had opposite effect choline glycerophospholipids. These data show for first time that distinct FABP differentially affect intracellular esterification.