Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis

• DOI: 10.1007/bf02681944
• Publication Date: 2007-08-15T20:00:13Z
• Authors: V. A. Korshunov; A. N. Murashev; M. N. Ivashev; S. F. Dugin; O. S. Medvedev
• Keywords: Monoamine oxidase inhibitor

Single intravenous injection of antidepressant tetrindol (1 and 10 mg/kg), a reversible monoamine oxidase A inhibitor, dose-dependently decreased heart rate and mean arterial pressure (in a concentration of 10 mg/kg) in alert NMRI mice and Sprague-Dawley rats. Nitric oxide synthase blockade with L-NAME attenuated tetrindol-induced bradycardia in rats and completely abolished this effect in mice.