Ability of a specific ERK signal-pathway inhibitor to reverse P-glycoprotein-mediated vincristine resistance in colon cancer cell lines

• DOI: 10.1007/bf02739816
• Publication Date: 2007-11-04T07:28:49Z
• Authors: Feng Jin; Hua Fan; Bo Chen; Ping Lu; Fan Yao; Huimian Xu; Shubao Wang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Objective To investigate the effect of a specific inhibitor PD098059 of the extracellular-signal regulated protein kinase (ERK) pathway on the P -glycoprotein (P-gp)-mediated resistance of colon cancer cell lines SW480/ VCR and CoLo205A/CR.