Distribution and excretion of3H-rhomotoxin in mice

• DOI: 10.1007/bf02911456
• Publication Date: 2010-06-22T17:47:20Z
• Authors: Liu Yong-jia; Wang Ya-zhen; Mao Huan-yuan; Guo He-ping; Liu Shu-mao; Cai Xi-lin; Cai Yi-hua; Shen De-cun; Sun Jia-xiu; Sun Zhi-wei
• Keywords: Mice; Animals; Tissue Distribution; Blood Proteins; Diterpenes; Tritium; Protein Binding; 3. Good health

The distribution and excretion of intravenous injected3H-rhomotoxin was studied in mice. The radioactivity of3H-rhomotoxin was found to be high in gall bladder, liver and kidney, lower in thyroid gland, adrenal gland, heart and lungs, and lowest in brain. 52.4% of the drug was excreted in urine and feces within 6 h. Rhomotoxin was bound to plasma protein (60 % at 30 min) and to some extent to liver and kidney tissue.