Cytotoxic constituents fromSolanum lyratum

• DOI: 10.1007/bf02974274
• Publication Date: 2008-10-30T01:19:32Z
• Authors: Li-Xin Sun; Wen-wei Fu; Jing Ren; Liang Xu; Kai-Shun Bi; Min-Wei Wang
• Keywords: Inhibitory Concentration 50; Dose-Response Relationship, Drug; Molecular Structure; Pregnenolone; Animals; Humans; Solanum; Antineoplastic Agents, Phytogenic; 01 natural sciences; HeLa Cells; 0104 chemical sciences

Activity-guided fractionation of the ethanol extract of the whole plant from Solanum lyratum resulted in the isolation of a new pregnane derivative glycoside, 16-dehydropregnenolone 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosid uronic acid (2), as well as other six known compounds: 16-dehydropregnenolone (1), allopregenolone (3), protocatechuic acid (4), vanillic acid (5), caffeic acid (6), and scopoletin (7). The structures of the isolated compounds were elucidated on the basis of their spectral data and chemical evidences. Compounds 1, 3, 4 were isolated for the first time from this plant. Cytotoxic activities of the isolated compounds were evaluated. Compound 1 exhibited significant cytotoxic activity against A375-S2, HeLa, SGC-7901, and Bel-7402 with IC50 values of 13.1 +/- 0.9, 21.5 +/- 1.0, 40.2 +/- 0.7, and 49.8 +/- 1.2 microg/mL, respectively.