Effects of lanthanide ions on hydrolysis of phosphatidylinositol in human erythrocyte membranes

• DOI: 10.1007/bf03183274
• Publication Date: 2010-03-15T12:18:35Z
• Authors: Huixue Liu; Jian Hu; Xiangtao Liu; Rongchang Li; Kui Wang
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; 3. Good health

The effects of lanthanides on the hydrolysis of phosphatidylinositol in human erythrocyte membranes were studied.3H-inositol labeling chromatography and HPLC were used to determine inositol 1, 4, 5-triphosphate and diacylglycerol separately, the hydrolytic products of phosphatidylinositol due to the reaction of lanthanide ions with human erythrocyte membranes. The unhydrolyzed phosphatidylinositol in membranes was also determined. The results indicate that the hydrolysis of phosphatidylinositol can be promoted by lanthanides (La3+, Ce3+, Y3+, Tb3+) and the effects of La3+ and Ce3+ are stronger than those of Y3+ and Tb3+.