Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat

• DOI: 10.1007/bf03189825
• Publication Date: 2010-08-04T01:09:25Z
• Authors: N. Feng; Z. Zhang; D. An; W. Huang; G. Wang; X. Han; X. Bao
• Keywords: Male; Rats, Sprague-Dawley; Magnetic Resonance Spectroscopy; Berberine; Animals; Anti-Arrhythmia Agents; 01 natural sciences; Rats; 0104 chemical sciences; 3. Good health

The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.