The (-174) G/C polymorphism in the interleukin-6 gene is associated with risk of papillary thyroid carcinoma in Turkish patients

• DOI: 10.1007/bf03346494
• Publication Date: 2014-03-28T17:55:10Z
• Authors: A. G. Özgen; M. Karadeniz; M. Erdogan; A. Berdeli; F. Saygili; C. Yilmaz
• Keywords: Adult; Male; 0301 basic medicine; Genotype; Turkey; Interleukin-6; (-174) G/C polymorphismin; Genetic Variation; DNA; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Carcinoma, Papillary; Statistics, Nonparametric; 3. Good health; interleukin-6 gene; 03 medical and health sciences; papillary thyroid carcinoma; Humans; Female; Genetic Predisposition to Disease; Thyroid Neoplasms; Alleles; Polymorphism, Restriction Fragment Length

Interleukins and cytokines play an important role in the pathogenesis of many cancers.We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in patients with papillary thyroid carcinoma (PTC) and control subjects.In this study, 42 patients with PTC and 340 healthy controls were included. Peripheral blood samples were taken from control group and patients, and blood samples were preserved at -80 C in tubes containing Na-EDTA.We also found a statistically significant difference between patients with PTC and the control group with respect to IL-6 genotype (p<0.05). IL-6 gene polymorphism in patients with PTC patients did not reveal statistically significant difference between the 2 groups (size of tumor >1 cm and <1 cm), multicentricity, RET-PTC types and capsule invasion (p>0.05).We also did not find a statistically significant difference between patients with PTC and the control group with respect to IL-6-gene allele frequency (p>0.05).Our data suggest that the IL-6 G-174 C polymorphism could play a role in thyroid cancer risk, but there is no effective role as a prognostic factor.