Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome

• DOI: 10.1007/bf03346755
• Publication Date: 2014-03-27T17:12:12Z
• Authors: Q. Cheng; W. Xia; S. Yang; P. Ye; M. Mei; Y. Song; M. Luo; Q. Li
• Keywords: Adult; Cholesterol, HDL; Cholesterol, LDL; Body Mass Index; 3. Good health; 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Humans; Insulin; Female; Testosterone; Nerve Growth Factors; Insulin Resistance; Eye Proteins; Serpins; Polycystic Ovary Syndrome

The basic studies showed that Pigment epithelium-derived factor (PEDF) plays an important role in inflammation.This study aims to investigate the association of serum PEDF with high-sensitivity C-reactive protein (hs-CRP) in women with polycystic ovary syndrome (PCOS).Ninety-six PCOS women and 63 healthy, age-matched controls were enrolled in this study. Serum levels of PEDF, hs-CRP, Complement C3 (C3), glucose, insulin, lipids, and total testosterone were measured. Ninety-six PCOS women and 20 controls underwent hyperinsulinemiceuglycemic clamp to assess their insulin sensitivity, which was expressed as M value.Serum PEDF levels and hs- CRP levels were much higher in PCOS women than in controls. In PCOS women, PEDF positively correlated with body mass index (BMI), hs-CRP, C3, LDL cholesterol (LDL-c), and systolic blood pressure (SBP), and negatively correlated with M value and HDL cholesterol (HDL-c). After controlling for BMI, PEDF was still positively correlated with hs-CRP. Multiple linear regression analysis revealed that in PCOS women, hs-CRP, SBP, LDL-c and M value were independent determinants of serum PEDF.The serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS.