Coordinate Changes in Myosin Heavy Chain Isoform Gene Expression Are Selectively Associated With Alterations in Dilated Cardiomyopathy Phenotype

• DOI: 10.1007/bf03402039
• Publication Date: 2018-09-06T08:45:54Z
• Authors: W. T. Abraham; E. M. Gilbert; B. D. Lowes; W. A. Minobe; P. Larrabee; R. L. Roden; D. Dutcher; J. Sederberg; J. A. Lindenfeld; E. E. Wolfel; S. F. Shakar; D. Ferguson; K. Volkman; J. V. Linseman; R. A. Quaife; A. D. Robertson; Michael R. Bristow
• Keywords: Dilated Cardiomyopathy; Atrial natriuretic peptide

The most common cause of chronic heart failure in the US is secondary or primary dilated cardiomyopathy (DCM). DCM phenotype exhibits changes expression genes that regulate contractile function and pathologic hypertrophy. However, it unclear if any these alterations gene are disease producing modifying.One approach to providing evidence for cause-effect a disease-influencing quantitatively compare by employing serial measurements longitudinal experimental design. We investigated quantitative relationships between n 47 patients with idiopathic DCM. In endomyocardial biopsies at baseline 6 months later, we measured mRNA regulating (beta-adrenergic receptors, sarcoplasmic reticulum Ca(2) + ATPase, alpha- beta-myosin heavy chain isoforms) associated hypertrophy (beta-myosin atrial natriuretic peptide), plus beta-adrenergic receptor protein expression. Left ventricular was assessed radionuclide ejection fraction.Improvement directly related coordinate increase decrease contrast, modification unrelated beta(1)- beta(2)-adrenergic protein, ATPase peptide.We conclude human DCM, phenotypic selectively myosin isoform changes. These data support hypothesis contribute progression