The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation

• DOI: 10.1007/bf03402177
• Publication Date: 2018-09-13T03:55:56Z
• Authors: Valentin A. Pavlov; Hong Wang; Christopher J. Czura; Steven G. Friedman; Kevin J. Tracey
• Keywords: Inflammation; 0301 basic medicine; 03 medical and health sciences; Neuroimmunomodulation; Immune System; Antibody Formation; Cholinergic Agents; Animals; Brain; Humans; Vagus Nerve; 3. Good health

This review outlines the mechanisms underlying interaction between nervous and immune systems of host in response to an challenge. The main focus is cholinergic anti-inflammatory pathway, which we recently described as a novel function efferent vagus nerve. pathway plays critical role controlling inflammatory through with peripheral a7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe modulation systemic local inflammation by its interface brain system. clinical implications this mechanism also are discussed.