Outcomes and Prognostic Factors for Squamous-Cell Carcinoma of the Anal Canal

• DOI: 10.1007/dcr.0b013e31819eb7f0
• Publication Date: 2011-04-07T17:22:04Z
• Authors: Karl Y. Bilimoria; David J. Bentrem; Colin E. Rock; Andrew K. Stewart; Clifford Y. Ko; Amy Halverson
• Keywords: Concordance; Univariate analysis; Cancer staging; Surgical oncology

PURPOSE: The objective of this study was to assess survival and prognostic factors for anal carcinoma in the population. METHODS: Patients with squamous-cell canal were identified from National Cancer Data Base (1985-2000). Univariate multivariable methods used associated survival. Concordance calculated agreement between American Joint Committee on stage actual outcome. RESULTS: Nineteen thousand one hundred ninety-nine patients (Stage I, 25.3 percent; Stage II, 51.8 III, 17.1 IV, 5.7 percent). Overall five-year 58.0 percent. (6th edition) staging system provided good discrimination by stage: 69.5 59.0 40.6 18.7 percent (concordance index, 0.663). On analysis, had a higher risk death if they male, ≥65 years old, black, living lower median incomes areas, more advanced T tumors, nodal or distant metastases, poorly differentiated cancers (P < 0.0001). There not significant difference hospital type year diagnosis. CONCLUSION: Although tumor characteristics affect prognosis, patient factors, such as gender, race, socioeconomic status, are also important canal.