Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia

• DOI: 10.1007/s00011-005-1357-6
• Publication Date: 2005-08-17T13:39:47Z
• Authors: C. Penido; K. A. Costa; R. J. Pennaforte; M. F. S. Costa; J. F. G. Pereira; A. C. Siani; M. G. M. O. Henri...
• Keywords: Inflammation; Limonins; 0301 basic medicine; 0303 health sciences; Dose-Response Relationship, Drug; Ovalbumin; Plant Extracts; Allergens; Bradykinin; Dinoprostone; Permeability; Rats; Capillary Permeability; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Models, Chemical; Hyperalgesia; Anti-Allergic Agents; Animals; Edema; Meliaceae; Histamine

We investigated the anti-allergic and analgesic properties of an oil and a derived fraction of tetranortriterpenoids (TNTP) obtained from the seeds of Carapa guianensis Aublet.Pleurisy, paw and ear edema were induced in Swiss and C57/Bl10 mice mice, whereas thermal hyperalgesia was assessed in Wistar rats (n = 6-10 per group). Values of p < 0.05 were regarded as significant.C. guianensis oil (100 to 400 mg/kg, p.o.) and TNTP (12.5 to 100 mg/kg, p.o.) inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice. TNTP (12.5 to 100 mg/kg, p.o.) also inhibited paw edema induced by histamine, PAF and bradykinin. TNTP (100 mg/kg, p.o.) inhibited prostaglandin E(2) generation in the pleural cavity in response to antigenic challenge. Moreover, C. guianensis oil (100 to 400 mg/kg) and TNTP (12.5 to 100 mg/kg) decreased OVA- and histamine-induced hyperalgesia.Taken together, these findings demonstrate the anti-edematogenic and analgesic effects of C. guianensis oil, and points out TNTP as the responsible bioactive compounds.