Two novel trichothecenes from Myrothecium roridum

• DOI: 10.1007/s00044-007-9012-0
• Publication Date: 2007-07-19T21:15:21Z
• Authors: Tao Wang; Yi Zhang; Yue-hu Pei
• Keywords: 01 natural sciences; 0104 chemical sciences

Two new trichothecenes, Roridin P and Isororidin P, and two known trichothecenes, Verrucarin A and Verrucarin J, were isolated from liquid cultures of Myrothecium roridum Tale ex Fr. The stereo-structures of Roridin P and Isororidin P were established on the basis of one- and two-dimensional nuclear magnetic resonance (NMR) spectral analyses. Roridin P and Isororidin P induced morphological changes in Pyricularia oryzae, with a minimum concentration (MMCC) value of 6.2 ± 1.1 μmol/L and 7.9 ± 1.5 μmol/L.