Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities

• DOI: 10.1007/s00044-022-02992-x
• Publication Date: 2022-11-10T05:05:26Z
• Authors: Feng Li; Chong Yang; Liang Zhang; Wenbao Li
• Keywords: Myricetin; Acarbose; Disaccharide

Abstract Myricetin is a common plant-derived flavonoid and exhibits a wide range of activities. However, myricetin also exhibits substantial limitations, such as its poor water-solubility and low stability in body when it was administrated by oral. To solve these problems, a series of myricetin derivatives with different disaccharide groups were designed, synthesized and evaluated their hypoglycemic activities. All synthesized compounds displayed significant α-glucosidase inhibitory activity in comparison with acarbose in vitro, which indicated that myricetin derivatives with different disaccharide groups had good hypoglycemic activity and could be further developed as hypoglycemic drugs.