Nonrigid Patient Setup Errors in the Head-and-Neck Region

• DOI: 10.1007/s00066-007-1747-5
• Publication Date: 2007-08-30T19:18:33Z
• Authors: Buelent Polat; Juergen Wilbert; Kurt Baier; Michael Flentje; Matthias Guckenbe...
• Keywords: Radiotherapy Planning, Computer-Assisted; Masks; Radiotherapy Dosage; Cone-Beam Computed Tomography; Immobilization; 03 medical and health sciences; Radiation Protection; 0302 clinical medicine; Head and Neck Neoplasms; Body Burden; Humans; Artifacts

To investigate the magnitude and clinical relevance of relative motion/nonrigid setup errors in the head-and-neck (H&N) region.Eleven patients with tumors in the H&N region were immobilized in thermoplastic head masks. Patient positioning was verified using a kilovoltage cone-beam CT (kv CBCT) prior to 100 treatment fractions. Five different regions of interest (ROIs) were selected for automatic image registration of planning CT and verification CBCT: (1) the whole volume covering planning CT and CBCT, (2) the skull, (3) the mandible, (4) C1-C3, and (5) C4-C6. Differences were calculated describing relative motion between the ROIs.The 3-D patient setup error was 3.2 mm +/- 1.7 mm based on registration of the whole volume. No systematic relative motion (group mean errors <0.5 mm and <0.5 degrees ) between planning and treatment for any ROI was observed. Mobility was largest for the skull and the mandible relative to C4-C6 with 3-D displacements of 4.7 mm +/- 2.5 mm and 4.4 mm +/- 2.5 mm. Relative rotations were largest around the left-right axis (nodding) between C1-C3 and C4-C6 with maximum 11 degrees . No time trend of relative motion was observed. Margins for compensation of relative motion ranged between 5 mm and 10 mm.The simplification of the patient as a rigid body was shown to result in significant errors due to relative motion in the H&N region. Margins for compensation of relative motion exceeded margins for compensation of patient positioning errors.