Long-term lifestyle intervention lowers the incidence of stroke in Japanese patients with type 2 diabetes: a nationwide multicentre randomised controlled trial (the Japan Diabetes Complications Study)

• DOI: 10.1007/s00125-009-1622-2
• Publication Date: 2010-01-06T11:59:02Z
• Authors: H. Sone; S. Tanaka; S. Iimuro; S. Tanaka; K. Oida; Y. Yamasaki; S. Oikawa; S. Ishibashi; S. Katayama; H. Yamashita; H. Ito; Y. Yoshimura; Y. Ohashi; Y. Akanuma; N. Yamada
• Keywords: Stroke; Outpatient clinic

The aim of the study was to clarify whether a therapeutic intervention focused on lifestyle modification affected incidence vascular complications in patients with established diabetes.A total 2,033 eligible Japanese men and women aged 40-70 years type 2 diabetes from 59 institutes were randomised conventional treatment group (CON), which continued receive usual care, (INT), received education regarding dietary habits, physical activities adherence by telephone counselling at each outpatient clinic visit, addition care. Randomisation open-label allocation done central computer system. Primary analysis measurements control status occurrence macro- microvascular based 1,304 participants followed for an 8 year period.Although most classic cardiovascular risk factors, including body weight, glycaemia, serum lipids BP, did not differ between groups during period, stroke INT (5.48/1,000 patient-years) significantly lower than CON (9.52/1,000 Kaplan- Meier (p=0.02 logrank test) multivariate Cox (HR 0.62, 95% CI 0.39-0.98, p=0.04). CHD, retinopathy nephropathy groups. Lipoprotein(a) another significant independent factor stroke.These findings suggest that had limited effects typical variables, but have effect diabetes.UMIN-CTR C000000222The Ministry Health, Labour Welfare, Japan