Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

• DOI: 10.1007/s00125-014-3266-0
• Publication Date: 2014-05-27T14:05:19Z
• Authors: Philipp A. Gerber; Elisa A. Bellomo; David J. Hodson; Gargi Meur; Antonia Solomou; Ryan K. Mitchell; Michael Hollinshead; Fabrice Chimienti; Domenico Bosco; Stephen J. Hughes; Paul R. V. Johnson; Guy A. Rutter
• Keywords: Hypoxia; BETA (programming language)

Hypoxic damage complicates islet isolation for transplantation and may contribute to beta cell failure in type 2 diabetes. Polymorphisms the SLC30A8 gene, encoding secretory granule zinc transporter 8 (ZnT8), influence diabetes risk, conceivably by modulating cytosolic Zn(2+) levels. We have therefore explored role of ZnT8 response hypoxia pancreatic cells.