A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control

• DOI: 10.1007/s00125-015-3636-2
• Publication Date: 2015-06-06T12:16:35Z
• Authors: Noha A. Yousri; Dennis O. Mook-Ka...; Mohammed M. El-Di...; Ahmed H. Takiddin; Hala Al-Homsi; Khoulood A. S. Al...; Edward D. Karoly; Jan Krumsiek; Kieu Thinh Do; Ulrich Neumaier; Marjonneke J. Moo...; Jillian Rowe; Omar M. Chidiac; Cindy McKeon; Wadha A. Al Muftah; Sara Abdul Kader; Gabi Kastenmüller; Karsten Suhre
• Keywords: Metabolic control analysis; Metabolome

Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of dysregulations across multiple biofluids over varying timescales glycaemic control is still lacking.Here we report broad metabolomics study clinical setting, covering 2,178 metabolite measures saliva, plasma from 188 individuals diabetes 181 controls Arab Asian descent. Using multivariate linear regression identified markers acute, short-term long-term control.Ninety-four associations were at Bonferroni level significance (p < 2.3 × 10(-5)), 16 which never reported. Sixty-five these diabetes-associated least one marker the group. Gaussian graphical modelling, constructed network that links three different control.Our reveals complex biochemical dysregulation involving pathways pathology, provides reference framework future studies endpoints.