Season of birth and the risk of type 2 diabetes in adulthood: a prospective cohort study of 0.5 million Chinese adults

• DOI: 10.1007/s00125-016-4200-4
• Publication Date: 2017-01-07T02:48:14Z
• Authors: Jiahui Si; Canqing Yu; Yu Guo; Zheng Bian; Xia Li; Ling Yang; Yiping Chen; Huarong Sun; Bo Yu; Junshi Chen; Zhengming Chen; Jun Lv; Liming Li
• Keywords: Season of birth

Season of birth as a surrogate for potential environmental exposure during fetal development and early postnatal life has shown an inconsistent association with adult type 2 diabetes in white populations living high-latitude regions. The present study aimed to examine the between seasonality risk Chinese individuals across wide regions low latitude lower middle latitude. Participants from China Kadoorie Biobank were enrolled 2004–2008 followed up until 31 December 2013. After excluding participants cancer, heart disease, stroke at baseline, included 189,153 men 272,058 women aged 30–79 years. We used multivariable Cox proportional hazards model estimate HR 95% CI. During median follow-up 7.2 years (3.3 million person-years), we documented 8784 incident cases diabetes. In whole cohort, compared summer-born participants, adjusted HRs (95% CIs) 1.09 (1.02, 1.16), 1.08 1.15) those who born Spring, Autumn Winter, respectively. was consistent both subgroups defined by residence lifestyle factors later life. this large prospective study, summer had other seasons birth, suggesting exposures some degree seasonal variation might influence