Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy

• DOI: 10.1007/s00125-017-4309-0
• Publication Date: 2017-05-25T04:38:12Z
• Authors: Klemens Fondi; Piotr A. Wozniak; Kinga Howorka; Ahmed M. Bata; Gerold C. Aschinger; Alina Popa-Cherec...; Katarzyna J. Witk...; Anton Hommer; Doreen Schmidl; René M. Werkmeister; Gerhard Garhöfer; Leopold Schmetterer
• Keywords: Oxygen Saturation

The aim of this study was to compare retinal oxygen extraction in individuals with diabetes no or mild non-proliferative diabetic retinopathy and healthy age- sex-matched volunteers. A total 24 participants type 1 volunteers were included cross-sectional study. Retinal measured by combining blood flow measurements using a custom-built bi-directional Doppler optical coherence tomography system saturation spectroscopic reflectometry. Based on previously published mathematical modelling, the content vessels calculated. Total higher (46.4 ± 7.4 μl/min) than (40.4 5.3 μl/min, p = 0.002 between groups). Oxygen arteries comparable two groups, but veins (0.15 0.02 ml O2/ml) compared control (0.13 O2/ml, < 0.001). As such, arteriovenous difference reduced (total 1.40 0.44 vs 1.70 0.47 μl O2/min, respectively, 0.03). Our data indicate early hypoxia as individuals. Further studies are required fully understand potential technique risk stratification treatment monitoring. ClinicalTrials.gov NCT01843114.