Assessment of glucose regulation in pregnancy after gastric bypass surgery

• DOI: 10.1007/s00125-017-4437-6
• Publication Date: 2017-09-16T00:03:37Z
• Authors: Christian S. Göbl; Latife Bozkurt; Andrea Tura; Michael Leutner; Laura Andrei; Lukas Fahr; Peter Husslein; Wolfgang Eppel; Alexandra Kautzky...
• Keywords: Carbohydrate Metabolism; Gastric bypass surgery; Glucose tolerance test

Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations following RYGB.Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control and normal weight women) were included. Frequently sampled 3 h OGTTs 1 IVGTTs performed between 24 28 weeks gestation and, a subgroup, repeated at 3-6 months delivery.We observed major kinetics during the OGTT, including an early increase plasma followed hypoglycaemia 90% had previously undergone RYGB. The higher degree variability group was accompanied increased insulin, C-peptide glucagon concentrations oral load, whereas no differences insulin response parenteral administration (RYGB vs weight). IVGTT data suggested improved sensitivity (mean difference 0.226 × 10-4 min-1 [pmol/l]-1 [95% CI 0.104, 0.348]; p < 0.001) disposition index pregnancies when compared with women. However, subtle action beta cell function still comparing normal-weight group. Moreover, we that fetal growth associated maternal nadir levels secretion offspring those RYGB.Pregnancies affected altered postprandial glucose, dynamics. Insulin although observed. Longitudinal needed assess potential consequences for development outcomes.