Size and shape of the associations of glucose, HbA1c, insulin and HOMA-IR with incident type 2 diabetes: the Hoorn Study

• DOI: 10.1007/s00125-017-4452-7
• Publication Date: 2017-10-10T10:02:45Z
• Authors: Carolien Ruijgrok; Jacqueline M. Dekker; Joline W. Beulens; Ingeborg A. Brouwer; Veerle M. H. Coupé; Martijn W. Heymans; Femke P. C. Sijtsma; David J. Mela; Peter L. Zock; Margreet R. Olthof; Marjan Alssema
• Keywords: Adult; Blood Glucose; Male; Incident type 2 diabetes; Fasting insulin; HOMA-IR; Article; 03 medical and health sciences; 0302 clinical medicine; SDG 3 - Good Health and Well-being; 2 h post-load glucose; Humans; Insulin; HbA; Aged; Glycated Hemoglobin; Fasting plasma glucose; Fasting; Glucose Tolerance Test; Middle Aged; 3. Good health; Glucose; Diabetes Mellitus, Type 2; Female; Insulin Resistance; Biomarkers

Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact interventions on risk diabetes incidence, we investigated size shape associations plasma glucose (FPG), 2 h post-load (2hPG), HbA1c, HOMA-IR with incident type mellitus.The study population included 1349 participants aged 50-75 years without at baseline (1989) from a population-based cohort in Hoorn, Netherlands. Incident was defined by WHO 2011 criteria or known follow-up. Logistic regression models were used to determine glycaemic markers, diabetes. Restricted cubic spline logistic regressions conducted investigate associations.After mean follow-up duration 6.4 (SD 0.5) years, 152 developed (11.3%); majority screen detected high FPG. In multivariate adjusted models, ORs (95% CI) for highest quintile comparison lowest 9.0 (4.4, 18.5) FPG, 6.1 (2.9, 12.7) 2hPG, 3.8 (2.0, 7.2) 1.9 (0.9, 3.6) 2.8 (1.4, 5.6) HOMA-IR. The FPG HbA1c non-linear, rising more steeply higher values.FPG most strongly associated diabetes, followed insulin. strong association is probably because frequent marker diagnosis. Non-linearity between should be taken into account when estimating future based markers.