Aberrant intestinal microbiota in individuals with prediabetes

• DOI: 10.1007/s00125-018-4550-1
• Publication Date: 2018-01-29T17:04:58Z
• Authors: Kristine H. Allin; Valentina Tremaroli; Robert Caesar; Benjamin A. H. Je...; Mads T. F. Damgaard; Martin I. Bahl; Tine R. Licht; Tue H. Hansen; Trine Nielsen; Thomas M. Dantoft; Allan Linneberg; Torben Jørgensen; Henrik Vestergaard; Karsten Kristiansen; Paul W. Franks; Torben Hansen; Fredrik Bäckhed; Oluf Pedersen
• Keywords: Prediabetes; Akkermansia; Ruminococcus; Akkermansia muciniphila

Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering diabetes-related microbial signatures. We tested whether specific microbiota profiles are associated prediabetes (defined as fasting plasma glucose 6.1–7.0 mmol/l or HbA1c 42–48 mmol/mol [6.0–6.5%]) a range clinical biomarkers poor metabolic health. In present case–control study, we analysed 134 Danish adults prediabetes, overweight, insulin resistance, dyslipidaemia low-grade inflammation age- sex-matched individuals normal regulation. found five bacterial genera 36 operational taxonomic units (OTUs) were differentially abundant between those At genus level, abundance Clostridium was decreased (mean log2 fold change −0.64 (SEM 0.23), p adj = 0.0497), whereas abundances Dorea, [Ruminococcus], Sutterella Streptococcus increased 0.51 0.12), 5 × 10−4; 0.11), 1 0.60 0.21), 0.0497; 0.92 4 10−4, respectively). The two OTUs differed most member order Clostridiales (OTU 146564) Akkermansia muciniphila, which both displayed lower among −1.74 0.41), 10−3 −1.65 0.34), Faecal transfer from donors screen-detected, drug-naive to germfree Swiss Webster conventional C57BL/6 J mice did not induce impaired regulation in recipient mice. Collectively, our data show characterised by mucin-degrading bacterium A. muciniphila. Our findings comparable observations overt chronic diseases inflammation.