Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study

• DOI: 10.1007/s00125-022-05651-3
• Publication Date: 2022-02-04T16:30:44Z
• Authors: Evelien J. Vander...; Annemarie Koster; Hans H. C. M. Sav...; Simone J. P. M. E...; Pieter C. Dagnelie; Nicolaas C. Schaper; Miranda T. Schram; Carla J. H. van d...; Marleen M. J. van...; Anke Wesselius; Casper G. Schalkwijk; Abraham A. Kroon; Ronald M. A. Henry; Coen D. A. Stehouwer
• Keywords: Prediabetes; Endothelial Dysfunction; Sedentary lifestyle

Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis CVD can potentially be modified by physical activity sedentary behaviour. Effects on biomarkers may especially prominent type 2 diabetes. Methods In population-based Maastricht Study ( n = 2363, 51.5% male, 28.3% diabetes, 15.1% prediabetes [defined as impaired glucose tolerance fasting glucose]), we determined inflammation, combined z scores were calculated. Physical behaviour measured activPAL. Linear regression analyses used with adjustment for demographic, lifestyle cardiovascular risk factors. Results The association between total, light, moderate-to-vigorous vigorous intensity time one hand other generally significant consistently stronger diabetes compared normal metabolism status p interaction <0.05). Associations also similar individuals without (pre)diabetes >0.05). Conclusions/interpretation associated inflammation. For dysfunction, associations than metabolism. Whether increasing or decreasing positively influence requires further study. Graphical abstract