Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study
Prediabetes
Endothelial Dysfunction
Sedentary lifestyle
DOI:
10.1007/s00125-022-05651-3
Publication Date:
2022-02-04T16:30:44Z
AUTHORS (14)
ABSTRACT
Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis CVD can potentially be modified by physical activity sedentary behaviour. Effects on biomarkers may especially prominent type 2 diabetes. Methods In population-based Maastricht Study ( n = 2363, 51.5% male, 28.3% diabetes, 15.1% prediabetes [defined as impaired glucose tolerance fasting glucose]), we determined inflammation, combined z scores were calculated. Physical behaviour measured activPAL. Linear regression analyses used with adjustment for demographic, lifestyle cardiovascular risk factors. Results The association between total, light, moderate-to-vigorous vigorous intensity time one hand other generally significant consistently stronger diabetes compared normal metabolism status p interaction <0.05). Associations also similar individuals without (pre)diabetes >0.05). Conclusions/interpretation associated inflammation. For dysfunction, associations than metabolism. Whether increasing or decreasing positively influence requires further study. Graphical abstract
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (46)
CITATIONS (49)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....