Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study
Male
EXERCISE
Low-grade inflammation
Article
MECHANISMS
Prediabetic State
03 medical and health sciences
Diabetes mellitus type 2
0302 clinical medicine
MARKERS
Humans
Endothelial dysfunction
Vascular Diseases
Exercise
Inflammation
INSULIN-RESISTANCE
OVERWEIGHT
Physical activity
MORTALITY
Sedentary behaviour
C-REACTIVE PROTEIN
TIME
3. Good health
Glucose
ATHEROSCLEROSIS
Diabetes Mellitus, Type 2
CARDIOVASCULAR-DISEASE
Female
Sedentary Behavior
Cohort study
Biomarkers
DOI:
10.1007/s00125-022-05651-3
Publication Date:
2022-02-04T16:30:44Z
AUTHORS (14)
ABSTRACT
Abstract
Aims/hypothesis
Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be especially prominent in type 2 diabetes.
Methods
In the population-based Maastricht Study (n = 2363, 51.5% male, 28.3% type 2 diabetes, 15.1% prediabetes [defined as impaired glucose tolerance and impaired fasting glucose]), we determined biomarkers of endothelial dysfunction and low-grade inflammation, and combined z scores were calculated. Physical activity and sedentary behaviour were measured by activPAL. Linear regression analyses were used with adjustment for demographic, lifestyle and cardiovascular risk factors.
Results
The association between total, light, moderate-to-vigorous and vigorous intensity physical activity and sedentary time on the one hand and biomarkers of endothelial dysfunction on the other were generally significant and were consistently stronger in prediabetes and type 2 diabetes as compared with normal glucose metabolism status (p for interaction <0.05). Associations between physical activity and sedentary behaviour on the one hand and low-grade inflammation on the other were also significant and were similar in individuals with and without (pre)diabetes (p for interaction >0.05).
Conclusions/interpretation
Physical activity and sedentary behaviour are associated with biomarkers of endothelial dysfunction and low-grade inflammation. For biomarkers of endothelial dysfunction, associations between physical activity and sedentary behaviour were consistently stronger in (pre)diabetes than in normal glucose metabolism. Whether increasing physical activity or decreasing sedentary time can positively influence biomarkers of endothelial dysfunction in individuals with prediabetes and type 2 diabetes requires further study.
Graphical abstract
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