Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial

• DOI: 10.1007/s00125-022-05797-0
• Publication Date: 2022-09-30T06:04:20Z
• Authors: Theresia Sarabhai; Lucia Mastrototaro; Sabine Kahl; Gidon J. Bönhof; Marc Jonuscheit; Pavel Bobrov; Hisayuki Katsuyama; Rainer Guthoff; Martin Wolkersdorfer; Christian Herder; Sven G. Meuth; Sven Dreyer; Michael Roden
• Keywords: Crossover study; Carbohydrate Metabolism

Hyperbaric oxygen (HBO) therapy may improve hyperglycaemia in humans with type 2 diabetes, but underlying mechanisms are unclear. Our objective was to examine the glucometabolic effects of HBO on whole-body glucose disposal diabetes.In a randomised placebo-controlled crossover trial located at German Diabetes Center, 12 male individuals diabetes (age 18-75 years, BMI <35 kg/m2, HbA1c 42-75 mmol/mol [6-9%]), randomly allocated by one person, underwent 2-h HBO, once 100% (240 kPa; HBO) and 21% control, CON). Insulin sensitivity assessed hyperinsulinaemic-euglycaemic clamps D-[6,6-2H2]glucose, hepatic skeletal muscle energy metabolism were 1H/31P-magnetic resonance spectroscopy, while high-resolution respirometry measured white adipose tissue (WAT) mitochondrial capacity. All participants people assessing outcomes blinded.HBO decreased fasting blood 19% increased whole-body, WAT insulin about one-third (p<0.05 vs Upon γ-ATP concentrations doubled, respiratory control doubled tripled myocellular insulin-stimulated serine-473/threonine-308 phosphorylation Akt basal inhibitory serine-1101 IRS-1 endoplasmic reticulum stress CON).HBO-mediated improvement likely results from capacity, possibly leading low-dose reactive species-mediated mitohormesis diabetes.ClinicalTrials.gov NCT04219215 FUNDING: Federal Ministry Health, Education Research, North-Rhine Westfalia Culture Science, European-Regional-Development-Fund, German-Research-Foundation (DFG), Schmutzler Stiftung.