Timing of physical activity in relation to liver fat content and insulin resistance

• DOI: 10.1007/s00125-022-05813-3
• Publication Date: 2022-11-01T00:04:30Z
• Authors: Jeroen H. P. M. v...; Sebastiaan C. Boone; Esther Winters-va...; Matthijs K. C. He...; Vera B. Schrauwen...; Patrick Schrauwen; Hildo J. Lamb; Frits R. Rosendaal; Renée de Mutsert
• Keywords: Human physiology

Abstract Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on timing activity. Here, we examined cross-sectional associations breaks in sedentary time and with liver fat content insulin resistance a Dutch cohort. Methods In 775 participants Netherlands Epidemiology Obesity (NEO) study, assessed time, different intensities using sensors, by magnetic resonance spectroscopy ( n =256). Participants were categorised as being most active morning (06:00–12:00 hours), afternoon (12:00–18:00 hours) or evening (18:00–00:00 engaging moderate-to-vigorous-physical (MVPA) evenly distributed throughout day. Most certain block was defined spending majority (%) total daily MVPA block. between HOMA-IR linear regression analyses, adjusted for demographic lifestyle factors including body fat. Associations additionally MVPA. Results The (42% men) had mean (SD) age 56 (4) years BMI 26.2 (4.1) kg/m 2 . Total not associated resistance, whereas amount higher content. (−5%/h [95% CI −10%/h, 0%/h]) reduced but Compared who an even distribution day, similar (−3% −25%, 16%]) those morning, it (−18% −33%, −2%]) (−25% −49%, −4%]). Conclusions/interpretation number lower resistance. Moderate-to-vigorous reduction up to 25% Further studies should assess whether is also important occurrence type diabetes. Graphical abstract