Increased endogenous carbon monoxide production in severe sepsis
Male
0301 basic medicine
Analysis of Variance
Carbon Monoxide
0303 health sciences
Comorbidity
3. Good health
Oxidative Stress
03 medical and health sciences
Breath Tests
Case-Control Studies
Sepsis
Humans
Female
Prospective Studies
APACHE
Aged
DOI:
10.1007/s00134-002-1269-7
Publication Date:
2003-01-16T20:59:55Z
AUTHORS (5)
ABSTRACT
A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis.Prospective comparative study.Medical ICU in a community hospital.Twenty-four patients with severe sepsis of various etiologies and five control patients with varying diagnoses.CO concentration was determined with an infrared CO analyzer on exhaled breath collected at the outlet of the ventilator. Endogenous CO production was estimated by the lung CO excretion rate measured at steady state.: Endogenous CO production was higher in the sepsis group during the first 3 days of treatment in comparison to the control group (10.9+/-5 (SD) microl/kg per h on day 1, 7.8+/-4.9 microl/kg per h on day 2 and 6.9+/-4.7 microl/kg per h on day 3 versus 2.1+/-0.5 microl/kg per h; p<0.01 for each comparison). Survivors of sepsis had a significantly higher endogenous CO production on day 1 compared to non-survivors (14.7+/-5.3 versus 8.5+/-3.3 microl/kg per h; p=0.02).Endogenous CO production was significantly higher in mechanically ventilated patients suffering from severe sepsis. Further studies are required in order to determine the mechanism(s) and the functional significance of this increase.
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