Aerosolized β2-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure

• DOI: 10.1007/s00134-002-1282-x
• Publication Date: 2003-01-16T20:59:55Z
• Authors: Kamran Atabai; Lorraine B. Ware; Mary E. Snider; Patrick Koch; Brian Daniel; Thomas J. Nuckton; Michael A. Matthay
• Keywords: Aerosols; Male; Respiratory Distress Syndrome; Dose-Response Relationship, Drug; Pulmonary Edema; Adrenergic beta-Agonists; Middle Aged; Respiration, Artificial; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Extravascular Lung Water; Humans; Albuterol; Female; Hospital Mortality; APACHE; Aged; Retrospective Studies

Experimental studies demonstrate that beta-adrenergic agonists markedly stimulate alveolar fluid clearance if concentrations of 10(-6) M are achieved in alveolar fluid. However, no studies have determined whether aerosolized beta-adrenergic agonists are delivered to the distal air spaces of the lung in therapeutic concentrations in patients with pulmonary edema.This retrospective study measured albuterol levels in the pulmonary edema fluid and plasma from mechanically ventilated patients with pulmonary edema from a hydrostatic mechanism ( n=10) or from acute lung injury ( n=12).After a total aerosolized albuterol dose of 4.2+/-3.2 mg in the prior 6 h the median pulmonary edema fluid albuterol level was 1,250 ng/ml (10(-6) M) in patients with hydrostatic pulmonary edema; after 3.5+/-2.6 mg the figure was 1,240 ng/ml (10(-6) M) in patients with pulmonary edema from acute lung injury. Plasma albuterol levels were much lower, with a median of 5.2 ng/ml (0.01 x 10(-6) M) in patients with hydrostatic pulmonary edema and 3.1 ng/ml (0.01 x 10(-6) M) in patients with pulmonary edema from acute lung injury.These results provide the first evidence that levels of beta-adrenergic agonists that are physiologically efficacious in experimental models can be achieved with conventional delivery systems in ventilated, critically ill patients with acute respiratory failure from pulmonary edema.