Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study

• DOI: 10.1007/s00134-017-4805-1
• Publication Date: 2017-05-05T05:29:10Z
• Authors: Estelle Peronnet; Fabienne Venet; Delphine Maucort-...; Arnaud Friggeri; Martin Cour; Laurent Argaud; Bernard Allaouchiche; Bernard Floccard; Frédéric Aubrun; Thomas Rimmelé; Fabrice Thiolliere; Vincent Piriou; Julien Bohé; Marie-Angélique C...; Véronique Barbalat; Guillaume Monneret; Stéphane Morisset; Julien Textoris; Hélène Vallin; Alexandre Pachot; Alain Lepape
• Keywords: CD74

Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs mortality. To date, no biomarker has shown sufficient evidence ease of application clinical routine for the identification patients at risk IAI. We evaluated association systemic mRNA expression two host response biomarkers, CD74 IL10, with IAI occurrence a large cohort patients.ICU were prospectively enrolled multicenter study. Whole blood was collected on day admission (D1) 3 (D3) 6 (D6) after admission. Patients screened daily data censored diagnosis. levels biomarkers measured using RT-qPCR. Fine Gray competing models used to assess between gene occurrence.A total 725 analyzed. At least one episode occurred 137 (19%). After adjustment shock sepsis status admission, IL10 found be significantly associated [subdistribution hazard ratio (95% confidence interval) 0.67 (0.46-0.97) D3/D1 2.21 (1.63-3.00) D3]. cumulative incidence different groups stratified according or (Gray tests p < 0.001).Our results suggest that immune could relevant tools patients.