Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study

• DOI: 10.1007/s00134-022-06811-0
• Publication Date: 2022-07-14T15:04:59Z
• Authors: Todd A. Miano; Sean Hennessy; Wei Yang; Thomas G. Dunn; Ariel R. Weisman; Oluwatosin Oniyide; Roseline S. Agyekum; Alexandra P. Turner; Caroline A. G. It...; Brian J. Anderson; F. Perry Wilson; Raymond Townsend; John P. Reilly; Heather M. Giannini; Christopher V. Co...; Tiffanie K. Jones; Nuala J. Meyer; Michael G. S. Sha...
• Keywords: Piperacillin/tazobactam; Tazobactam

Although dozens of studies have associated vancomycin + piperacillin-tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true or a pseudotoxicity characterized by isolated effects on creatinine secretion. We tested this hypothesis contrasting changes in concentration after antibiotic initiation cystatin C concentration, biomarker unaffected tubular