Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication

• DOI: 10.1007/s00213-011-2479-x
• Publication Date: 2011-10-05T04:39:01Z
• Authors: Eef L. Theunissen; Gerold F. Kauert; Stefan W. Toennes; Manfred R. Moeller; Anke Sambeth; Mathieu M. Blanchard; Johannes G. Ramae...
• Keywords: Delta-9-tetrahydrocannabinol; Dronabinol; Crossover study; Tetrahydrocannabinol; Effects of cannabis; Δ9-tetrahydrocannabinol; Drug tolerance

Experienced cannabis users demonstrate tolerance to some of the impairing acute effects cannabis.The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy after Δ9-tetrahydrocannabinol (THC) administration, as a result tolerance.Twelve 12 participated in double-blind, placebo-controlled, crossover study. On two separate days, they smoked joint containing 0 or 500 μg/kg body weight THC. ERPs were measured while subjects performed divided attention task (DAT) stop signal (SST).In DAT, THC significantly decreased P100 amplitude but not users. P300 DAT was by both groups. The N200 peak SST affected treatment neither Performance impaired groups treatment, whereas performance only group.The confirms that develop behavioral cannabis. This also evident underlying ERPs, suggesting demonstrated on level is (completely) due compensation.