Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration

• DOI: 10.1007/s00213-013-3333-0
• Publication Date: 2013-11-23T03:21:59Z
• Authors: A. Aristieta; T. Morera-Herreras; J. A. Ruiz-Ortega; C. Miguelez; I. Vidaurrazaga; A. Arrue; M. Zumarraga; L. Ugedo
• Keywords: Subthalamic Nucleus; Dorsal raphe nucleus

Within the basal ganglia, subthalamic nucleus (STN) is only glutamatergic structure and occupies a central position in indirect pathway. In rat, STN receives serotonergic input from dorsal raphe expresses receptors. This study examined consequences of neurotransmission modulation on neuron activity. vivo single-unit extracellular recordings, HPLC determination, rotarod bar test were performed control, 4-chloro-DL-phenylalanine methyl ester hydrochloride- (pCPA, serotonin synthesis inhibitor) chronically fluoxetine-treated rats. The pCPA treatment administration (5-HT) receptor antagonists increased number bursting neurons STN. systemic 5-HT1A agonist, 8-OH-DPAT, decreased firing rate coefficient variation pCPA-treated rats but not control animals. Additionally, microinjection 8-OH-DPAT into reduced neurons, while 5-HT2C Ro 60-0175, both Finally, fluoxetine challenge induced catalepsy. Our results indicate that depletion blockage 5-HT modify pattern. activity under receptors located inside outside increases rats, which may explain role this fluoxetine-induced extrapyramidal side effects.