Alcohol devaluation has dissociable effects on distinct components of alcohol behaviour

• DOI: 10.1007/s00213-018-4839-2
• Publication Date: 2018-02-26T06:18:27Z
• Authors: Abigail K Rose; Kyle Brown; James MacKillop; Matt Field; Lee Hogarth
• Keywords: Extinction (optical mineralogy); Attentional Bias; Cue reactivity

Substance-related behaviour is often viewed as an appetitive behaviour, motivated by the reinforcing effects of drug. However, there are various indices substance motivation (e.g. attentional bias, behavioural economic demand, craving) and it unclear how these related or whether they play important role in all types substance-related behaviour.(1) To determine effect alcohol devaluation on several goal-directed cue-elicited behaviour. (2) investigate which components mediate any behaviour.Sixty-two social drinkers gave baseline measures craving, demand choice for vs. soft drink. Participants tasted was either unadulterated (control) adulterated with a bitter solution (devaluation) before craving were measured again. Alcohol assessed phases: extinction (evaluating behaviour), presence drink cues (Pavlovian-to-instrumental transfer (PIT, behaviour)), reacquisition. Attentional bias (AB) tracking eye movements towards during novel PIT trials where both presented. Finally, consumption evaluated taste test.Alcohol reduced alcohol-related AB, phases, consumption. presented increased above irrespective devaluation. AB fully mediated extinction, (specific PIT) consumption.Alcohol largely sensitive to devaluation, i.e. governed current motivational value drug (suggesting behaviour). dissociable form stimulus control can also drive alcohol-seeking independently PIT). Mediation analyses suggests that may paradoxical forms seeking