Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice

• DOI: 10.1007/s00213-019-05406-w
• Publication Date: 2019-12-02T10:36:33Z
• Authors: Zhang Hai-Na; Yu Xu-Ben; Tang Cong-Rong; Cao Yan-Cheng; Yang Fan; Xu Lei-Mei; Sun Ruo-Lan; Ye-Zi; Wang Ye-Xuan; Liang Jing
• Keywords: Inflammation; Male; Dose-Response Relationship, Drug; Depression; Tumor Necrosis Factor-alpha; Anti-Inflammatory Agents; Prefrontal Cortex; Hippocampus; Streptozocin; Diabetes Mellitus, Experimental; 3. Good health; Mice; 03 medical and health sciences; 0302 clinical medicine; Hindlimb Suspension; Atorvastatin; Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators

Depression is a chronic and progressive syndrome and commonly associated with several neuropsychiatric comorbidities, of which depression is the most studied. It has been demonstrated that statins also have anti-inflammatory and immunomodulatory properties, which being explored for potential benefits in depression. However, the role of statins in the treatment of diabetes-related depression has not been well examined. Herein, we investigated the effects of atorvastatin on depressive behaviors and neuroinflammation in streptozotocin-induced diabetic mice. Our data indicated that oral administration of atorvastatin at 10 or 20 mg/kg for 3 weeks markedly ameliorated diabetes-associated depressive behaviors reflected by better performance in sucrose preference test (SPT), tail suspension test (TST), and novelty-suppressed feeding test (NSFT). The study further showed that atrovastatin decreased the expression of nucleus NF-κB p65 expression and ameliorated neuroinflammatory responses in prefrontal cortex as evidenced by less Iba-1-positive cells and lower inflammatory mediators including IL-1β and TNF-α. As expected, atorvastatin-treated diabetic mice exhibited significant improvement of hyperlipidemia rather than hyperglycemia. These results suggest that atorvastatin has the potential to be employed as a therapy for diabetes-related depression.