Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD

• DOI: 10.1007/s00213-020-05636-3
• Publication Date: 2020-09-04T04:25:59Z
• Authors: D. M. Eagle; C. Schepisi; S. Chugh; S. Desai; S. Y. S. Han; T. Huang; J. J. Lee; C. Sobala; W. Ye; A. L. Milton; T. W. Robbins
• Keywords: Quinpirole; Dysfunctional family

Abstract Rationale Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive disorder (OCD), checking may escalate dysfunctional levels. The processes underpinning the transition from are unclear but be associated with individual differences support development of maladaptive We examined one such predisposition, sign-tracking pavlovian conditioned stimulus, which we previously found checking. How interacts another treatment emerging translational validity for OCD-like checking, chronic administration dopamine D 2 receptor agonist quinpirole, unknown. Objectives tested how and rat observing response task (ORT) was affected by quinpirole non-autoshaped controls autoshaped animals classified as sign-trackers or goal-trackers. Methods Sign-trackers goal-trackers were trained on ORT before effects assessed. Subsequently, different behavioural challenges, including reward omission use unpredictable reinforcement schedules, tested. Results Prior autoshaping increased responded differently sensitization, uncertainty. showed greater elevations particularly during By contrast, predominantly responses, possibly reduced discrimination accuracy absence cues signalling lever currently active. Conclusions results discussed terms associations influence becomes compulsive OCD this dependent striatal receptors.