Current and future requirements to industrial analytical infrastructure—part 1: process analytical laboratories

• DOI: 10.1007/s00216-020-02420-2
• Publication Date: 2020-02-15T03:02:24Z
• Authors: Kristina Eisen; Tobias Eifert; Christoph Herwig; Michael Maiwald
• Keywords: Process Analytical Technology; Process development

Abstract The competitiveness of the chemical and pharmaceutical industry is based on ensuring required product quality while making optimum use plants, raw materials, energy. In this context, effective process control using reliable analytics secures global competitiveness. setup those strategies often originate in development but need to be transferable along whole life cycle. series two contributions, we want present a combined view future PAT (process analytical technology), which projected smart labs (part 1) sensors 2). laboratories pilot offline methods are frequently used, where inline also used production. Here, transferability from operation would desirable. This can obtained by establishing for production already during or scale-up. However, current (Bakeev 2005, Org Process Res 19:3–62; Simon et al. 2015, Dev 19:3–62) must become more flexible smarter. achieved introducing digitalization-based knowledge management, so that enables accelerates integration PAT. Conversely, will contribute development. contribution describes role laboratory develops requirements therefrom. part 2, examine functionality as well ingredients sensor aiming eventually fuel full functionality—also within scale-up facilities (Eifert 2020, Anal Bioanal Chem).