Soleus H-reflex modulation in cerebral palsy and its relationship with neural control complexity: a pilot study

• DOI: 10.1007/s00221-022-06399-3
• Publication Date: 2022-06-25T16:02:51Z
• Authors: Benjamin C. Conner; Alyssa M. Spomer; Safoura Sadegh Po...; Katherine M. Steele; Zachary F. Lerner
• Keywords: H-Reflex; 03 medical and health sciences; 0302 clinical medicine; Adolescent; Electromyography; Cerebral Palsy; Humans; Pilot Projects; Walking; Child; Muscle, Skeletal

Individuals with cerebral palsy (CP) display motor control patterns that suggest decreased supraspinal input, but it remains unknown if they are able to modulate lower-limb reflexes in response to more complex tasks, or whether global motor control patterns relate to reflex modulation capacity in this population. Eight ambulatory individuals with CP (12-18 years old) were recruited to complete a task complexity protocol, where soleus H-reflex excitability was compared between bilateral (baseline) and unilateral (complex) standing. We also investigated the relationship between each participant's ability to modulate soleus H-reflex excitability and the complexity of their walking neural control pattern determined from muscle synergy analysis. Finally, six of the eight participants completed an exoskeleton walking protocol, where soleus H-reflexes were collected during the stance phase of walking with and without stance-phase plantar flexor resistance. Participants displayed a significant reduction in soleus H-reflex excitability (- 26 ± 25%, p = 0.04) with unilateral standing, and a strong positive relationship was observed between more refined neural control during walking and an increased ability to modulate reflex excitability (R = 0.79, p = 0.04). There was no difference in neuromuscular outcome measures with and without the ankle exoskeleton (p values all > 0.05), with variable reflex responses to walking with ankle exoskeleton resistance. These findings provide evidence that ambulatory individuals with CP retain some capacity to modulate lower-limb reflexes in response to increased task complexity, and that less refined neural control during walking appears to be related to deficits in reflex modulation.