Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History

• DOI: 10.1007/s00223-009-9221-2
• Publication Date: 2009-02-20T20:31:06Z
• Authors: Timothy G. Bromage; Rodrigo S. Lacruz; Russell Hogg; Haviva M. Goldman; Shannon C. McFarlin; Johanna Warshaw; Wendy Dirks; Alejandro Perez-O...; Igor Smolyar; Donald H. Enlow; Alan Boyde
• Keywords: Osteocyte; Lamella (surface anatomy); Skeleton (computer programming); Bone tissue

Mammalian enamel formation is periodic, including fluctuations attributable to the daily biological clock as well longer-period oscillations that enigmatically correlate with body mass. Because scaling of bone mass an axiom vertebrate hard tissue biology, we consider long-period rhythms may reflect corresponding and heretofore unrecognized in growth. The principal aim this study seek a rhythm growth demonstrably related oscillatory development. Our analytical approach based morphology, using variety microscopy techniques. We first ascertain relationship among rhythms, striae Retzius, large sample mammalian taxa. In addition, test whether osteocyte lacuna density (a surrogate for rates cell proliferation) correlated Finally, fluorescently labeled developing tissues, investigate lamella, fundamental microanatomical unit bone, relates rhythmic increments. results confirm positive correlation between negative also lamellar incremental tissue, one lamella formed species-specific time dependency Retzius formation. conclude by contextualizing our morphological research current understanding autonomic regulatory control skeleton mass, suggesting central contribution coordination organismal life history