Variability in drug metabolizing enzyme activity in HIV-infected patients

• DOI: 10.1007/s00228-009-0777-6
• Publication Date: 2010-01-18T14:39:17Z
• Authors: Amanda E. Jones; Kevin C. Brown; Rebecca E. Werner; Karl Gotzkowsky; Andrea Gaedigk; Mike Blake; David W. Hein; Charles van der H...; Angela D. M. Kashuba
• Keywords: CYP3A; Paraxanthine; Dextrorphan; CYP2A6; Midazolam

To evaluate variability in cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, N-acetyltransferase 2 (NAT2), and xanthine oxidase (XO) activity in HIV-infected patients and compare this with data from uninfected, healthy volunteers.