Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir

• DOI: 10.1007/s00228-011-1180-7
• Publication Date: 2011-12-15T09:13:37Z
• Authors: Michael W. Jann; Vicky Spratlin; Kathryn Momary; Hailing Zhang; David Turner; Scott R. Penzak; Alan Wright; Chad VanDenBerg
• Keywords: Adult; Male; Dose-Response Relationship, Drug; Metabolic Clearance Rate; Venlafaxine Hydrochloride; Capsules; Indinavir; HIV Protease Inhibitors; Cyclohexanols; Antidepressive Agents; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Delayed-Action Preparations; Desvenlafaxine Succinate; Humans; Drug Interactions; Female; Selective Serotonin Reuptake Inhibitors; Half-Life; Tablets

To assess the effects of venlafaxine extended-release (XR) capsules and desvenlafaxine extended-release (XR) tablets upon indinavir pharmacokinetic properties when co-administrated to healthy volunteers.This was an open-label, two-period, fixed-dose study conducted at the clinical research unit located on a university campus. Twenty-four healthy volunteers enrolled in the study (mean age 28.3 ± 8.0 years). Each subject received a single dose of indinavir 800 mg on day 1. Subsequently, subjects were then randomly assigned to either the venlafaxine XR group (N = 12) or the desvenlafaxine XR group (N = 12). Starting on day 2, venlafaxine XR was dosed at 37.5 mg/day for 4 days and increased to 75 mg/day for 6 days. Desvenlafaxine XR was dosed at 50 mg/day for 10 days. On day 12, indivanvir 800 mg was co-administered to both the venlafaxine XR and the desvenlafaxine XR groups. The pharmacokinetics of indinavir were determined both before and at the end of antidepressant dosing. Plasma indinavir, venlafaxine, and desvenlafaxine concentrations were assayed by high-performance liquid chromatography with ultra-violet (UV) detection. Indinavir pharmacokinetic parameters were calculated by noncompartmental analysis using validated computer software.Venlafaxine XR and desvenlafaxine XR did not produce any significant changes in indinavir disposition. Both antidepressants were well tolerated by the subjects with only minor adverse side effects.No pharmacokinetic drug-drug interaction was demonstrated between venlafaxine XR and indinavir or between desvenlafaxine XR and indinvair. The lack of interaction could be due to the venlafaxine and desvenlafaxine extended-release formulation.