Perfusion imaging of brain gliomas using arterial spin labeling: correlation with histopathological vascular density in MRI-guided biopsies
Adult
Gadolinium DTPA
Image-Guided Biopsy
Male
Neovascularization, Pathologic
Brain Neoplasms
Microcirculation
Contrast Media
Glioma
Middle Aged
03 medical and health sciences
Imaging, Three-Dimensional
0302 clinical medicine
Cerebrovascular Circulation
Image Interpretation, Computer-Assisted
Humans
Female
Spin Labels
Neoplasm Grading
Magnetic Resonance Angiography
Aged
Retrospective Studies
DOI:
10.1007/s00234-016-1756-0
Publication Date:
2016-12-06T08:03:53Z
AUTHORS (9)
ABSTRACT
This study was designed to determine if cerebral blood flow (CBF) derived from arterial spin labeling (ASL) perfusion imaging could be used to quantitatively evaluate the microvascular density (MVD) of brain gliomas on a "point-to-point" basis by matching CBF areas and surgical biopsy sites as accurate as possible.The study enrolled 47 patients with treatment-naive brain gliomas who underwent preoperative ASL, 3D T1-weighted imaging with gadolinium contrast enhancement (3D T1C+), and T2 fluid acquisition of inversion recovery (T2FLAIR) sequences before stereotactic surgery. We histologically quantified MVD from CD34-stained sections of stereotactic biopsies and co-registered biopsy locations with localized CBF measurements. The correlation between CBF and MVD was determined using Spearman's correlation coefficient. P ≤ .05 was considered statistically significant.Of the 47 patients enrolled in the study, 6 were excluded from the analysis because of brain shift or poor co-registration and localization of the biopsy site during surgery. Finally, 84 biopsies from 41 subjects were included in the analysis. CBF showed a statistically significant positive correlation with MVD (ρ = 0.567; P = .029).ASL can be a useful noninvasive perfusion MR method for quantitative evaluation of the MVD of brain gliomas.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (38)
CITATIONS (24)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....